FEBS Letters | |
Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum | |
Bataille, D.1  Rosselin, G.1  Gespach, C.1  Mutt, V.3  Jörnvall, H.2  Tatemoto, K.3  | |
[1] INSERM U.55, Hôpital Saint-Antoine, 75571 Paris Cedex 12, France;Department of Biochemistry I, Karolinska Institute, S 10401 Stockholm, Sweden;Department of Biochemistry II, Karolinska Institute, S 10401 Stockholm, Sweden | |
关键词: Glucagon-37; Oxyntomodulin; Bioactive enteroglucagon; Amino acid sequence; Immunology; Biological activity; | |
DOI : 10.1016/0014-5793(82)80709-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A peptide isolated from porcine gut according to its glucagon-like activity in liver (bioactive enteroglucagon) has been characterized immunologically, biologically and chemically: its potency relative to pancreatic glucagon in interacting with an antiglucagon antibody, hepatic glucagon-binding sites and hepatic adenylate cyclase was ∼100%, 20% and 10%, respectively. In contrast, it is ∼20-times more potent than glucagon in oxyntic glands, justifying the term ‘oxyntomodulin’. Chemically, it consists in the 29 amino acid-peptide glucagon elongated at its C-terminal end by the octapeptide Lys—Arg—Asn—Lys—Asn—Asn—Ile &—Ala; accordingly, it is called ‘glucagon-37’
【 授权许可】
Unknown
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