A new role for enteric glucagon‐37: acute stimulation of glucose absorption in rat small intestine

FEBS Letters

Scholtka, Bettina¹  Jungermann, Kurt¹  Stümpel, Frank¹ 

[1] Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität, Humboldtallee 23, 37073 Göttingen, Germany

关键词: Glucagon-37;    Oxyntomodulin;    Glucose absorption;   

DOI  :  10.1016/S0014-5793(97)00628-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucagon-37 is secreted by intestinal L-cells following carbohydrate uptake. It is known to inhibit gastric acid secretion (hence also named oxyntomodulin) and appears to increase intracellular cyclic AMP concentrations. Since cyclic AMP could enhance intestinal glucose absorption, a possible stimulatory effect of glucagon-37 on glucose transport was examined. Glucagon-37 acutely increased glucose absorption in the isolated, vascularly perfused small intestine and in isolated enterocytes of the rat. In these cells the stimulation by glucagon-37 could be completely blocked by the cAMP antagonist Rp-cAMPS and was therefore mediated by cAMP. The stimulation of intestinal glucose absorption by glucagon-37 appears to be a major new physiological function.

【 授权许可】

Unknown