Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum

FEBS Letters

Carlqvist, M.²  Bataille, D.¹  Rosselin, G.¹  Mutt, V.²  Coudray, A.M.¹ 

[1] INSERM U.55, Hôpital Saint-Antoine, 75571 Paris Cedex 12, France;Department of Biochemistry II, Karolinska Institute, S-10401 Stockholm, Sweden

关键词: Glucagon-37;    Oxyntomodulin;    Bioactive enteroglucagon;    Isolation;    Porcine jejuno-ileum;   

DOI  :  10.1016/0014-5793(82)80708-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A 37 amino acid-peptide has been isolated from porcine jejuno-ileum on the basis of its glucagon-like activity in liver (interaction with glucagon-binding sites and activation of adenylate cyclase) using gel filtration, ion-exchange and high-performance liquid chromatography. Depending on the criteria chosen, this peptide is referred to as either ‘bioactive enteroglucagon’ (activity in liver), ‘oxyntomodulin’ (specific action in gastric oxyntic glands) or ‘glucagon-37’ (chemical structure).

【 授权许可】

Unknown