FEBS Letters | |
Oxyntomodulin (glucagon‐37) and its C‐terminal octapeptide inhibit gastric acid secretion | |
Niel, Huguette2  Dubrasquet, Marcelle1  Jarrousse, Claire2  Audousset-Puech, Marie-Pascale2  Martinez, Jean2  Bataille, Dominique2  | |
[1] Hôpital Bichat, INSERM U.10, 170 Boulevard Ney, 75018 Paris, France;Centre CNRS-INSERM de Pharmacologie-Endocrinologie, BP 5055, 34033 Montpellier CedexFrance | |
关键词: Oxyntomodulin; Rat; Cat; Acid secretion; Pentagastrin; | |
DOI : 10.1016/0014-5793(85)80879-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Oxyntomodulin (OXM) is a peptide isolated from porcine intestine which consists of the whole glucagon sequence with a basic octapeptide (KA8) at its C-terminal end. In this study, the effect of OXM and KA8 on pentagastrin-stimulated gastric acid secretion has been studied in conscious rats and cats. In rats, OXM (25–450 pmol·kg−1) as well as KA8 (7.5–60 nmol·kg−1) inhibited pentagastrin-stimulated gastric acid output in a dose-dependent manner; KA8 was about 100-times less potent than OXM. In cats, KA8 (90 nmol·kg−1) was also an inhibitor of acid secretion. We conclude that OXM, or a closely related peptide, could be a physiological modulator of gastric acid secretion, and that the C-terminal octapeptide of OXM is implicated in this effect.
【 授权许可】
Unknown
【 预 览 】
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