Oxyntomodulin (glucagon‐37) and its C‐terminal octapeptide inhibit gastric acid secretion

FEBS Letters

Niel, Huguette²  Dubrasquet, Marcelle¹  Jarrousse, Claire²  Audousset-Puech, Marie-Pascale²  Martinez, Jean²  Bataille, Dominique² 

[1] Hôpital Bichat, INSERM U.10, 170 Boulevard Ney, 75018 Paris, France;Centre CNRS-INSERM de Pharmacologie-Endocrinologie, BP 5055, 34033 Montpellier CedexFrance

关键词: Oxyntomodulin;    Rat;    Cat;    Acid secretion;    Pentagastrin;   

DOI  :  10.1016/0014-5793(85)80879-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oxyntomodulin (OXM) is a peptide isolated from porcine intestine which consists of the whole glucagon sequence with a basic octapeptide (KA₈) at its C-terminal end. In this study, the effect of OXM and KA₈ on pentagastrin-stimulated gastric acid secretion has been studied in conscious rats and cats. In rats, OXM (25–450 pmol·kg⁻¹) as well as KA₈ (7.5–60 nmol·kg⁻¹) inhibited pentagastrin-stimulated gastric acid output in a dose-dependent manner; KA₈ was about 100-times less potent than OXM. In cats, KA₈ (90 nmol·kg⁻¹) was also an inhibitor of acid secretion. We conclude that OXM, or a closely related peptide, could be a physiological modulator of gastric acid secretion, and that the C-terminal octapeptide of OXM is implicated in this effect.

【 授权许可】

Unknown