Impaired stimulation of intestinal glucose absorption by portal insulin via hepatoenteral nerves in chronically ethanol‐intoxicated rats

FEBS Letters

Jungermann, Kurt¹  Stümpel, Frank¹  Kucera, Tomas¹ 

[1] Institute of Biochemistry and Molecular Cell Biology, Georg-August-University, Humboldtallee 23, 37073 Göttingen, Germany

关键词: Glucose absorption;    Ethanol-induced neuropathy;    Cholinergic nerve;    Autonomic nervous system;   

DOI  :  10.1016/S0014-5793(00)01608-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the isolated, jointly perfused small intestine and liver of rats insulin, infused into the portal vein, induced an increase in intestinal glucose absorption via hepatoenteral cholinergic nerves. The possible loss of function of these nerves due to ethanol-induced neuropathy was investigated with 6 weeks ethanol-fed rats. Portal insulin or arterial carbachol failed to increase intestinal glucose absorption but cAMP still did so. The intact stimulatory effect of cAMP indicated an undisturbed capacity of the enterocytes. The loss of action of portal insulin and of arterial carbachol can be explained by the impairment of the hepatoenteral nerves in line with an ethanol-induced neuropathy.

【 授权许可】

Unknown