Tumor Cell Metabolism Imaging

Journal of Nuclear Medicine

Christian Plathow¹  Wolfgang A. Weber¹ 

关键词: glucose metabolism;    amino acid metabolism;    lipid metabolism;    PET;    optical imaging;    MRI;   

DOI  :  10.2967/jnumed.107.045930

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.

【 授权许可】

Unknown