Ferroptosis: Biochemistry and Biology in Cancers

Frontiers in Oncology

Huimin Sun¹  Chen Shao²  Jianzhong Zheng²  Zhiyuan Shi²  Lei Zhang³ 

[1] Clinical Central Research Core, Xiang’an Hospital of Xiamen University, Xiamen, China;Department of Urology, Xiang’an Hospital of Xiamen University, Xiamen, China;School of Public Health, Xiamen Univerisity, Xiamen, China;

关键词: ferroptosis;    cancers;    amino acid metabolism;    iron metabolism;    lipid metabolism;   

DOI  :  10.3389/fonc.2021.579286

来源: DOAJ

【 摘 要 】

The challenge of eradicating cancer is that cancer cells possess diverse mechanisms to protect themselves from clinical strategies. Recently, ferroptosis has been shown to exhibit appreciable anti-tumor activity that could be harnessed for cancer therapy in the future. Ferroptosis is an iron-dependent form of regulated cell death that is characterized by the oxidization of polyunsaturated fatty acids (PUFAs) and accumulation of lipid peroxides. Ferroptosis has been closely correlated with numerous biological processes, such as amino acid metabolism, glutathione metabolism, iron metabolism, and lipid metabolism, as well as key regulators including GPX4, FSP1, NRF2, and p53. Although ferroptosis could be involved in killing various cancer cells, multiple aspects of this phenomenon remain unresolved. In this review, we summarize the biochemistry and biology of ferroptosis in diverse cancers and discuss the potential mechanisms of ferroptosis, which might pave the way for guiding cancer therapeutics.

【 授权许可】

Unknown