Emerging Roles of the Tumor Suppressor p53 in Metabolism

Frontiers in Cell and Developmental Biology

Lili Yu¹  Meng Wu²  Yang Xu³  Gaoyang Zhu⁵ 

[1] Cancer Center, Zhejiang University, Hangzhou, China;Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States;Key Laboratory of Cancer Prevention and Intervention, Department of Medical Oncology, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan, China;

关键词: p53;    glucose metabolism;    lipid metabolism;    ferroptosis;    amino acid metabolism;    iron metabolism;   

DOI  :  10.3389/fcell.2021.762742

来源: DOAJ

【 摘 要 】

Metabolism plays critical roles in maintaining the homeostasis of cells. Metabolic abnormalities are often considered as one of the main driving forces for cancer progression, providing energy and substrates of biosynthesis to support neoplastic proliferation effectively. The tumor suppressor p53 is well known for its roles in inducing cell cycle arrest, apoptosis, senescence and ferroptosis. Recently, emerging evidence has shown that p53 is also actively involved in the reprogramming of cellular metabolism. In this review, we focus on recent advances in our understanding of the interplay between p53 and metabolism of glucose, fatty acid as well as amino acid, and discuss how the deregulation of p53 in these processes could lead to cancer.

【 授权许可】

Unknown