Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

Frontiers in Oncology

Oncology

Shuo Zhang¹  Bo Zhang¹  Qiubo Lv¹  Qingwei Meng¹  Dan Zhou¹  Jinbowen Yan¹  Fangzhi Xu² 

[1] Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China;The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology of National Health Commission, Beijing, China;

关键词: ovarian cancer;    platinum resistance;    metabolic reprogramming;    glucose metabolism;    lipid metabolism;    amino acid metabolism;   

DOI  :  10.3389/fonc.2023.1231460

 received in 2023-05-30, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle. These changes lead to the creation of metabolic intermediates that can provide precursors for the biosynthesis of cellular components and help maintain cellular energy homeostasis. This article reviews the research progress of the metabolic reprogramming mechanism of platinumbased chemotherapy resistance caused by three major nutrients in ovarian cancer.

【 授权许可】

Unknown   
Copyright © 2023 Yan, Xu, Zhou, Zhang, Zhang, Meng and Lv