Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

PLOS Pathogens

Lindsay D. Eltis¹  David G. Russell¹  Wonsik Lee¹  Yancheng Liu¹  Brian C. VanderVen¹  Ruth J. Fahey¹  Tiansheng Wang¹  David D. Deininger¹  Christopher P. Locher¹  Christine Memmott¹  Emanuele Perola¹  Robert B. Abramovitch¹  Adam M. Crowe¹ 

关键词: Mycobacterium tuberculosis;    Cholesterol;    Macrophages;    Drug metabolism;    Tuberculosis drug discovery;    Propionates;    Enzyme inhibitors;    Enzyme metabolism;   

DOI  :  10.1371/journal.ppat.1004679

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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