Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

PLOS Pathogens

Katherine A. Fitzgerald¹  Áine Burke¹  Sarah Smeaton¹  Jurg Tschopp¹  Vitor E. Fernandes¹  Andres Mori¹  Rana El-Rachkidy¹  Ed C. Lavelle¹  Barry Moran¹  Aras Kadioglu¹  Daniela Ferreira¹  Edel A. McNeela¹  Peter W. Andrew¹  Daniel R. Neill¹  Rachel M. McLoughlin¹  Cathy Baxter¹  Virginie Pétrilli¹ 

关键词: Secretion;    Cytokines;    Pneumococcus;    T cells;    Toxins;    Inflammasomes;    Respiratory infections;    Pneumonia;   

DOI  :  10.1371/journal.ppat.1001191

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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