FY2003 LDRD Final Annual Report Article: Pathogen Pathway Project

Fitch, J P ; McCutchen-Maloney, S L

Lawrence Livermore National Laboratory

关键词: Lawrence Livermore National Laboratory;    99 General And Miscellaneous//Mathematics, Computing, And Information Science;    59 Basic Biological Sciences;    Vaccines;    Secretion;   

DOI  :  10.2172/15013753
RP-ID  :  UCRL-TR-201339
RP-ID  :  W-7405-ENG-48
RP-ID  :  15013753

美国|英语

来源: UNT Digital Library

【 摘 要 】

Understanding virulence mechanisms of bacterial pathogens is vital to anticipating biological threats and to improving detectors, vaccines, and treatments. This project will characterize factors responsible for virulence of Yersinia pestis, the causative agent of plague and a biothreat agent, which has an inducible Type III secretion virulence mechanism also found in other animal, plant, and human pathogens. Our approach relies on genomic and proteomic characterization of Y. pestis in addition to a bioinformatic infrastructure. Scientific and technical capabilities developed in this project can be applied to other microbes of interest. This work will establish a significant new direction for biodefense at LLNL and expand our national and international scientific collaborations.