The neutrophil-to-lymphocyte ratio is associated with multiple sclerosis

Multiple Sclerosis Journal – Experimental, Translational and Clinical

ICHasselbalch¹ 

关键词: Multiple sclerosis;    relapsing-remitting;    systemic inflammation;    neutrophil-to-lymphocyte ratio;    multiple sclerosis severity score;    C-reactive protein;   

DOI  :  10.1177/2055217318813183

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundSubtypes of white blood cell counts are known biomarkers of systemic inflammation and a high neutrophil-to-lymphocyte ratio (NLR) has been associated with several autoimmune diseases. Few studies have investigated the NLR in multiple sclerosis (MS).ObjectiveTo examine the association between NLR, MS and disability measured by the MS severity score (MSSS).MethodsPatients were included from the Danish Multiple Sclerosis Biobank. Information on patient NLR was obtained just before their first treatment and clinical information was provided by the Danish Multiple Sclerosis Treatment Register. Information on NLR from controls was collected from the Danish Blood Donor Study. Patients and controls were 1:2 propensity score matched by baseline confounders.ResultsPropensity score matching left 740 of 743 MS patients and 1420 of 4691 controls for further analyses. Odds-ratio (OR) was 3.64 (95% confidence interval 2.87–4.60, p < 0.001) for MS disease per unit increase of logarithmically transformed NLR (ln...

【 授权许可】

CC BY-NC