Systemic inflammation in both open-angle and angle-closure glaucoma: role of platelet-to-lymphocyte ratio

Bratislava Medical Journal

article

M. Karahan¹  D. Kilic²  S. Guven² 

[1] Dicle University Faculty of Medicine, Department of Ophthalmology;Health Science University, Kayseri City Hospital, Department of Ophthalmology

关键词: neutrophil-to-lymphocyte ratio;    platelet-to-lymphocyte-ratio;    primary open-angle glaucoma;    primary angle-closure glaucoma;    systemic inflammation;   

DOI  :  10.4149/BLL_2021_005

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

AIM: To analyse the effect of systemic inflammatory status in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) by calculating platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). METHODS: This retrospective case-control study included 200 patients with POAG, 22 patients with PACG and 100 healthy subjects. The participants’ white-blood-cell, lymphocyte, neutrophil, and platelet counts were recorded from previous blood assays. NLR and PLR were calculated manually. Results were compared among the groups. RESULTS: Both the POAG and PACG groups had higher platelet counts and PLR values than the control group (p=0.001 and p=0.001; respectively). The difference in NLR between POAG, PACG and control groups was not statistically significant (p=0.076). The POAG group had higher NLR values than the control (p=0.035). CONCLUSION: Both the POAG and the PACG groups exhibited higher platelet and PLR levels than the control. These results indicate a potential role of systemic inflammation in the pathogenesis of POAG and PACG (Tab. 4, Fig. 1, Ref. 35).

【 授权许可】

CC BY