The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

PLoS One

Tomasz Brudek¹  Xiuqing Zhang¹  Xinjie Wang¹  Palle Villesen²  Anders L. Kjeldbjerg³  Magdalena J. Laska⁴  Tingting Wu⁴  Thor Petersen⁴  Sandra Bonnesen⁴  Mette Nyegaard⁴  Bettina Hansen⁴  Anne Hedemand⁴  Bjørn A. Nexø⁴  Kari K. Nissen⁴  Finn S. Pedersen⁴  Tove Christensen⁵  Anné Møller-Larsen⁵  Romana Maric⁵  Helle B. Søndergaard⁵  Henrik B. Rasmussen⁶  Anders D. Børglum⁷  Trine S. Petersen⁷  Jette Frederiksen⁸  Finn Sellebjerg⁹  Annette B. Oturai⁹  Klaus Brusgaard⁹  Anders L. Nielsen^1,10 

[1] BGI-Shenzhen, Shenzhen, China;Bioinformatics Research Center, University of Aarhus, Aarhus C, Denmark;Department of Clinical Genetics, Odense University Hospital, Odense, Denmark;Department of Human Genetics, University of Aarhus, Aarhus C, Denmark;Department of Medical Microbiology, University of Aarhus, Aarhus C, Denmark;Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark;Department of Neurology, Aarhus University Hospital, Aarhus C, Denmark;Department of Neurology, Glostrup Hospital, Glostrup, Denmark;Department of Neurology, The Danish Multiple Sclerosis Research Center, Copenhagen University Hospital, Copenhagen, Denmark;Research Institute of Biological Psychiatry, Psychiatry Center Sct. Hans, Roskilde, Denmark

关键词: Multiple sclerosis;    Retroviruses;    Genetic loci;    Etiology;    Mammalian genomics;    Viral genomics;    X chromosomes;    Human genetics;   

DOI  :  10.1371/journal.pone.0016652

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

【 授权许可】

CC BY