Human herpesvirus 6 infection as a trigger of multiple sclerosis: an update of recent literature

BMC Neurology

M. Chondrogianni¹  K. Foska¹  K. I. Voumvourakis¹  D. K. Kitsos¹  P.C. Fragkou²  S. Tsiodras² 

[1] 2nd Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece;4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece;

关键词: Cerebrospinal fluid;    CSF;    Demyelination;    Diagnosis;    HHV-6;    Human herpes virus 6,IgG antibodies;    IgM antibodies;    Multiple sclerosis;    Pathogenesis,pcr;    Polymerase Chain Reaction;    Polymorphisms;    Serology;    Etiology;   

DOI  :  10.1186/s12883-022-02568-7

来源: Springer

【 摘 要 】

BackgroundThis is an update on the existing evidence regarding a relationship between infection with human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) in order to contribute on the attempt to define the nature and strength of that relationship.ResultsStudy quality was assessed using the criteria proposed by Moore and Wolfson and by the classification criteria used by the Canadian Task Force on the Periodic Health Examination. Studies were categorized both by experimental technique and by quality (high [A], intermediate [B], and low [C]) as determined by the Moore and Wolfson criteria. Overall, 27 (90%) of 30 studies, 18 (86%) of which were classified as A quality, reached a statistically significant result. According to the Canadian Task Force classification, all studies were categorized as evidence of qualityII-1. Limitations of the available experimental techniques and perspectives for future research are discussed.ConclusionsThe current review continues to emphasize the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and multiple sclerosis.

【 授权许可】

CC BY