Clinical Drug Development for the Treatment of Pulmonary Arterial Hypertension: Collaboration With the Pharmaceutical Industry and Regulatory Agencies

Advances in Pulmonary Hypertension

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关键词: Cardiology;    Pulmonology;    Pediatrics;    Psychosocial Issues;    Lifestyle Issues;    WHO Group 1- Pulmonary Arterial Hypertension;    PH Medications;    Potential Therapies;    Surgical Interventions;    symptoms;    Research;    early childhood;    Cardiopulmonary rehabilitation;    Genetics;    Oral therapy;    IV therapy;    Phosphodiesterase Inhibitors (PDE-5 Inhibitors);    pharmacokinetics;    nitric oxide;    Inotropes;    Non-invasive estimate of PVR;    Pulmonary vascular resistance;    endothelial dysfunction;    Micro Particles;    chest pain;    Pregnancy;    patient-reported outcomes;    Drug development;    clinical trial;    clinical trial endpoints;    REVEAL;    pre-clinical research;    Education;    CME;    Classification;    Epidemiology;   

DOI  :  

学科分类：医学（综合）

来源: Pulmonary Hypertension Association

【 摘 要 】

Pleural spaces are well drained using chest tubes. Our preference is to use 24 Fr Blake tubes, as drainage is excellent and patient comfort is maximized. For single lung transplants, closure of the thorocotomy follows standard practice with complete drainage of anterior and posterior spaces. For bilateral transplants, the sternum is approximated using No. 5 wires, one simple set in the midline and one figure-8 on each side of the midline. The remainder of closure follows the same tenets as the standard thorocotomy. Lastly, the double lumen endotracheal tube is exchanged for a single lumen tube and fiberoptic bronchoscopy is performed to assess the adequacy of the anastomosis and clear secretions.

【 授权许可】

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