Outcomes, Management, and Complications of Lung Transplantation for Pulmonary Hypertension

Advances in Pulmonary Hypertension

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关键词: Cardiology;    Pulmonology;    Rheumatology;    Pediatrics;    Psychosocial Issues;    WHO Group 1- Pulmonary Arterial Hypertension;    WHO Group 3- Pulmonary hypertension owing to lung disease;    /or hypoxia;    WHO Group 5- Pulmonary hypertension with unclear multifactorial mechanisms;    Pulmonary Function Tests;    Arterial blood gas;    Surgical Interventions;    symptoms;    Associated Diseases;    Connective Tissue Diseases;    Patent Ductus Arteriosus;    Chronic obstructive pulmonary disease (COPD);    Interstital lung disease (ILD);    bronchiolitis obliterans;    hematologic disorder;    vasculitis;    Medication Adherence;    pharmacokinetics;    contraindications;    Diuretics;    Spirometry;    Transplantation;    UNOS Lung Allocation Score;    primary graft dysfunction;    thromboendarterectomy;    Preserved ejection fraction;    endothelial proliferation;    endothelial dysfunction;    Micro Particles;    tricuspid regurgitation;    dyspnea;    edema;    hypoxia;    chest pain;    patient-reported outcomes;    Drug development;    clinical trial endpoints;    von Willebr;    Factor;    Angiogram;    Classification;    Epidemiology;   

DOI  :  

学科分类：医学（综合）

来源: Pulmonary Hypertension Association

【 摘 要 】

The issue of who and when to refer for lung transplant evaluation is dynamic requiring a full understanding of the current medical management strategies and outcomes as well as current regional transplant waiting times and survival. In addition, individual patient characteristics may portend to worse medical outcome (eg, nonresponse to epoprostenol) or contraindicate transplantation altogether (HIV-associated pulmonary hypertension [PH]). Therefore, the challenge is to select those patients whose outcome will be improved by transplantation and whose individual characteristics will not result in heightened risk of graft loss. Transplantation should be reserved until it is expected to offer a survival advantage in those patients who have failed the best available medical therapy.

【 授权许可】

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