MicroCT-Based Skeletal Models for Use in Tomographic Voxel Phantoms for Radiological Protection

Bolch, Wesley

University of Florida/Department of Nuclear and Radiological Engineering

关键词: Trabecular Bone;    Radiation Protection;    Adults;    Pediatrics;    Cavities;   

DOI  :  10.2172/978474
RP-ID  :  DOE/ID/14773
RP-ID  :  FG07-07ID14773
RP-ID  :  978474

美国|英语

来源: UNT Digital Library

【 摘 要 】

ABSTRACT The University of Florida (UF) proposes to develop two high-resolution image-based skeletal dosimetry models for direct use by ICRP Committee 2’s Task Group on Dose Calculation in their forthcoming Reference Voxel Male (RVM) and Reference Voxel Female (RVF) whole-body dosimetry phantoms. These two phantoms are CT-based, and thus do not have the image resolution to delineate and perform radiation transport modeling of the individual marrow cavities and bone trabeculae throughout their skeletal structures. Furthermore, new and innovative 3D microimaging techniques will now be required for the skeletal tissues following Committee 2’s revision of the target tissues of relevance for radiogenic bone cancer induction. This target tissue had been defined in ICRP Publication 30 as a 10-m cell layer on all bone surfaces of trabecular and cortical bone. The revised target tissue is now a 50-m layer within the marrow cavities of trabecular bone only and is exclusive of the marrow adipocytes. Clearly, this new definition requires the use of 3D microimages of the trabecular architecture not available from past 2D optical studies of the adult skeleton. With our recent acquisition of two relatively young cadavers (males of age 18-years and 40-years), we will develop a series of reference skeletal models that can be directly applied to (1) the new ICRP reference voxel man and female phantoms developed for the ICRP, and (2) pediatric phantoms developed to target the ICRP reference children. Dosimetry data to be developed will include absorbed fractions for internal beta and alpha-particle sources, as well as photon and neutron fluence-to-dose response functions for direct use in external dosimetry studies of the ICRP reference workers and members of the general public