Gelam honey increases antioxidant enzyme activity in young rat cardiac mitochondria

International Journal of Biomedical and Advance Research

Siti Maisarah Hasenan ; Zulaikha Sahhugi ; Zakiah Jubri

关键词: s Aging;    Reactive oxygen species;    Antioxidant enzymes;    Oxidative damage;    Gelam honey;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Objective: The aim of this study is to determine the effect of gelam honey on antioxidant enzyme activity in cardiac mitochondria of young and aged rats. Methods: Twenty-four male Spraque-Dawley rats were divided into young (2 months) and aged (19 months) groups. Each group was further divided into control (fed with plain water) and supplemented with 2.5 g/kg body weight of gelam honey for 8 months. Results: Gelam honey increases cardiac manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx) activities in young. Malondialdehyde (MDA) level was reduced in gelam honey supplemented young group. Gelam honey increases cytochrome oxidase activity in the young group compared to control. Conclusions: Gelam honey reduces the oxidative damage and increase mitochondrial function by increasing antioxidant enzymes and cytochrome oxidase activity in the young group.

【 授权许可】

CC BY