Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

Nutrition & Metabolism

Lila Missae Oyama¹  Aline de Piano Ganen¹  Claudia Maria da Penha Oller do Nascimento¹  Eliane Beraldi Ribeiro¹  Elisa Esposito²  Valter Tadeu Boldarine¹  Nelson Inácio Pinto Neto¹  Marcos Hiromu Okuda¹  Bruno dos Santos¹  Ana Claudia Losinskas Hachul¹  Gabriel Inácio de Morais Honorato de Souza¹  Mayara Franzoi Moreno¹ 

[1] Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brazil;Instituto de Ciências e Tecnologia da Universidade Federal de São Paulo, São José dos Campos, SP, Brazil

关键词: IL-10;    Cytokines;    Mesenteric adipose tissue;   

Others  :  802647
DOI  :  10.1186/1743-7075-11-15

 received in 2013-11-19, accepted in 2014-03-22,  发布年份 2014

【 摘 要 】

Background

Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet.

Methods

Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)].

Results

The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue.

Conclusions

High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu.

【 授权许可】

   
2014 Moreno et al.; licensee BioMed Central Ltd.

【 图 表 】

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