Reactive astrogliosis in response to hemorrhagic fever virus: microarray profile of Junin virus-infected human astrocytes

Virology Journal

Slobodan Paessler¹  Nadezhda E Yun¹  Olga A Kolokoltsova¹ 

[1] Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, USA

关键词: Neurodegeneration;    Inflammation;    Apoptosis;    Interferon;   

Others  :  1148894
DOI  :  10.1186/1743-422X-11-126

 received in 2014-04-24, accepted in 2014-07-01,  发布年份 2014

【 摘 要 】

Background

Arenavirus Junin is the causative agent of Argentine hemorrhagic fever. Limited information is available concerning the pathogenesis of this human disease, especially the pathogenesis of acute and late neurological symptoms.

Methods

In our study we present for the first time cDNA microarray profile of human astrocytes infected with the virulent strain of Junin virus. Transcriptional profiling was confirmed by quantitative real-time RT-PCR and cytokine/chemokine/growth factor assay.

Results

We demonstrated the impact of virus infection on immune/inflammatory response/interferon signaling and apoptosis. Pro-apoptotic response and amplification with time of pro-inflammatory cascade of human astrocytes suggested neurodegenerative dysfunctional reactive astrogliosis in response to Junin virus infection.

Conclusion

Our results suggest potential pathogenic role of astroglial cells in the development of neurological symptoms and late neurological syndrome during Argentine hemorrhagic fever.

【 授权许可】

   
2014 Kolokoltsova et al.; licensee BioMed Central Ltd.

【 图 表 】

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