Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis

Cardiovascular Diabetology

Yasuki Kihara¹  Takayuki Hidaka¹  Eiji Kunita¹  Hideya Yamamoto¹  Hiroto Utsunomiya¹ 

[1] Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

关键词: Visceral adipose tissue;    Speckle-tracking echocardiography;    Insulin resistance;    Cardiac function;    Aortic valve sclerosis;   

Others  :  793049
DOI  :  10.1186/1475-2840-13-86

 received in 2014-02-13, accepted in 2014-04-20,  发布年份 2014

【 摘 要 】

Background

Insulin resistance, as a key mediator of metabolic syndrome, is thought to be associated with pathogenesis of calcific aortic valve disease and altered left ventricular (LV) function and structure. However, in patients with aortic valve sclerosis (AVS), the association between insulin resistance and subclinical impairment of LV function is not fully elucidated.

Methods

We studied 57 patients (mean age 70 ± 8 years, 22 women) with asymptomatic AVS but normal LV ejection fraction in echocardiography. LV longitudinal and circumferential strain and strain rate was analyzed using two-dimensional speckle tracking echocardiography. Patients with uncontrolled hypertension and diabetes mellitus, chronic kidney disease, and concomitant coronary artery disease were excluded. They were divided into the insulin-resistant group (AVS+IR; N = 28) and no insulin-resistant group (AVS-IR; N = 29) according to the median value of homeostatic model assessment index. Computed tomography scans were also performed to measure the aortic valve calcium score and the visceral adipose tissue (VAT) area. In addition, age- and sex- adjusted 28 control subjects were recruited for the comparison.

Results

There were no significant differences in LV ejection fraction or mass index among the groups. The AVS+IR group had a higher aortic valve calcium score (median 94 versus 21, P = 0.022) and a larger VAT area (113 ± 42 cm² versus 77 ± 38 cm², P = 0.001) than the AVS-IR group. Notably, LV global longitudinal strain, strain rate (SR), and early diastolic SR were significantly lower in the AVS+IR group than in the AVS-IR group and in control subjects (strain: -16.2 ± 1.6% versus -17.2 ± 1.2% and -18.9 ± 0.8%; SR: -1.18 ± 0.26 s^-1 versus -1.32 ± 0.21 s^-1 and -1.52 ± 0.08 s^-1; early diastolic SR: -1.09 ± 0.23 s^-1 versus -1.23 ± 0.18 s^-1 and -1.35 ± 0.12 s^-1; P < 0.05 for all comparison), whereas circumferential function were not significantly different. Multiple linear regression analyses revealed insulin resistance as an independent determinant of LV longitudinal strain (P = 0.017), SR (P = 0.047), and early diastolic SR (P = 0.049) regardless of LV mass index or VAT area.

Conclusions

Insulin resistance is a powerful independent predictor of subclinical LV dysfunction regardless of concomitant visceral obesity and LV hypertrophy. Thus, it may be a novel therapeutic target to prevent subsequent heart failure in patients with AVS.

【 授权许可】

   
2014 Utsunomiya et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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