ADIPOQ polymorphisms are associated with insulin resistance in Japanese women

Endocrine Journal

Takato Ueno^3,16  Seika Kamohara^3,15  Yuji Matsuzawa¹⁰  Aya Kitamoto^1,3  Shigeru Miyazaki⁵  Kiyoji Tanaka¹¹  Ikuo Mineo³  Atsushi Nakajima^3,17  Masato Yoneda^3,17  Kikuko Hotta^1,3  Hidenori Ochi¹³  Takuya Kitamoto^1,3  Yuji Ogawa^3,17  Takahiro Nakamura^3,8  Nobuyuki Miyatake^2,3  Hideyuki Hyogo¹³  Katsuto Tokunaga^3,6  Shinichi Oikawa⁷  Toshiie Sakata^3,18  Yoshio Nakata¹¹  Toshiaki Hanafusa^3,12  Tohru Funahashi^3,19  Kazuaki Chayama¹³  Kazuyuki Hamaguchi^4,20  Tomoaki Matsuo¹¹  Hiroaki Masuzaki¹⁴  Kazuaki Kotani¹⁰  Rina So¹¹  Jun Wada⁹  Kentaro Yamada⁴ 

[1]Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan

[2]Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan

[3]Otemae Hospital, Osaka 540-0008, Japan

[4]Division of Endocrinology and Metabolism, Department of Medicine, Kurume University, Kurume 830-0011, Japan

[5]Tokyo Postal Services Agency Hospital, Tokyo 102-8798, Japan

[6]Itami City Hospital, Itami 664-8540, Japan

[7]Director of Diabetes and Lifestyle Disease Center, Fukujuji Hospital, Tokyo 204-8522, Japan

[8]Laboratory for Mathematics, National Defense Medical College, Tokorozawa 359-8513, Japan

[9]Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan

[10]Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan

[11]Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8574, Japan

[12]Department of Internal Medicine (I), Osaka Medical College, Takatsuki 569-8686, Japan

[13]Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan

[14]Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan

[15]Health Science University, Yamanashi 401-0380, Japan

[16]Research Center for Innovative Cancer Therapy, Kurume University, Kurume 830-0011, Japan

[17]Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan

[18]Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita 879-5593, Japan

[19]Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan

[20]Department of Practical Nursing Science, Faculty of Medicine, Oita University, Oita 879-5593, Japan

关键词: ADIPOQ;    Single nucleotide polymorphism;    Visceral adipose tissue;    Insulin resistance;    Adiponectin;   

DOI  :  10.1507/endocrj.EJ14-0574

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(1)Visceral fat accumulation contributes to the development of insulin resistance, leading to metabolic syndrome. Adiponectin provides a link between visceral fat accumulation and insulin resistance.In addition to environmental factors, genetic factors play important roles in visceral fat accumulation and circulating adiponectin levels.Genome-wide association studies (GWASs) have identified genetic variations in the adiponectin, C1Q and collagen domain containing (ADIPOQ) gene that are associated with adiponectin levels.In this study, we investigated whether ADIPOQ single nucleotide polymorphisms (SNPs) were associated with visceral fat accumulation and insulin resistance.We measured the visceral fat area (VFA) by computed tomography (CT) and examined the presence of the insulin resistance-related phenotype (fasting plasma glucose, fasting insulin, and homeostasis model assessment-insulin resistance [HOMA-IR]) in a set of Japanese individuals (731 men and 864 women) who were genotyped for seven ADIPOQ SNPs reported by recent GWASs (namely, rs6810075, rs10937273, rs1648707, rs864265, rs182052, rs17366568, and rs6773957).SNPs associated with the phenotype (P < 0.05) were then evaluated by association analysis using a second set of the study participants (383 men and 510 women).None of the SNPs was associated with body mass index (BMI) or VFA in men or women.However, the adiponectin-decreasing alleles of rs10937273 and rs1648707 were significantly associated with HOMA-IR (P = 0.0030 and P = 0.00074, respectively) in women, independently of BMI.These SNPs were significantly associated with decreased adiponectin levels in women.Our results suggested that rs10937273 and rs1648707 may affect insulin sensitivity by regulating adiponectin production by adipose tissue in women.

【 授权许可】

Unknown