Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis

Cilia

Rachel H Giles¹  Sander G Basten¹ 

[1] Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, F03.223, 3584 CX, The Netherlands

关键词: Cancer;    Cell cycle;    Signal transduction;    Cilia;   

Others  :  791739
DOI  :  10.1186/2046-2530-2-6

 received in 2012-11-30, accepted in 2013-03-25,  发布年份 2013

【 摘 要 】

Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can eventually result in the development of ciliopathies: pathologically diverse diseases that range from clinically mild to highly complex and severe multi-organ failure syndromes incompatible with neonatal life. Given that virtually all cells of the human body have the capacity to generate cilia, it is likely that clinical manifestations attributed to ciliary dysfunction will increase in the years to come. Disputed but nevertheless enigmatic is the notion that at least a subset of tumor phenotypes fit within the ciliopathy disease spectrum and that cilia loss may be required for tumor progression. Contending for the centrosome renders ciliation and cell division mutually exclusive; a regulated tipping of balance promotes either process. The mechanisms involved, however, are complex. If the hypothesis that tumorigenesis results from dysfunctional cilia is true, then why do the classic ciliopathies only show limited hyperplasia at best? Although disassembly of the cilium is a prerequisite for cell proliferation, it does not intrinsically drive tumorigenesis per se. Alternatively, we will explore the emerging evidence suggesting that some tumors depend on ciliary signaling. After reviewing the structure, genesis and signaling of cilia, the various ciliopathy syndromes and their genetics, we discuss the current debate of tumorigenesis as a ciliopathy spectrum defect, and describe recent advances in this fascinating field.

【 授权许可】

   
2013 Basten and Giles; licensee BioMed Central Ltd.

【 图 表 】

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