Relationship between central and peripheral fatty acids in humans

Lipids in Health and Disease

Ross Grant¹  Ayse Bilgin³  Manohar Garg²  Jade Guest⁴ 

[1] Sydney Adventist Hospital Clinical School, University of Sydney, Sydney, NSW, Australia;Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Newcastle, NSW, Australia;Department of Statistics, Macquarie University, North Ryde, NSW, Australia;Australasian Research Institute, Sydney Adventist Hospital, Sydney, NSW, Australia

关键词: Omega-6;    Omega-3;    Blood brain barrier;    Cerebrospinal fluid;    Whole blood;    Brain;    Polyunsaturated fatty acids;    Fatty acids;   

Others  :  834614
DOI  :  10.1186/1476-511X-12-79

 received in 2013-04-15, accepted in 2013-05-09,  发布年份 2013

【 摘 要 】

Background

In recent years the physiological and pathological importance of fatty acids in both the periphery and central nervous system (CNS) has become increasingly apparent. However surprisingly limited research has been conducted comparing the fatty acid composition of central and peripheral lipid stores.

Methods

The present study compared the distribution of polyunsaturated (PUFA), as well as specific saturated (SFA) and monounsaturated (MUFA) fatty acids in the whole blood and cerebrospinal fluid (CSF) of humans. Gas chromatography with flame ionization detection was used to determine the fatty acid profiles of twenty-eight matched CSF and whole blood samples. Multiple linear regression modeling, controlling for age, was used to identify significant relationships.

Results

A significant positive relationship was seen between whole blood total omega-3 fatty acids and the CSF omega-3 subfractions, docosapentaenoic acid (DPA) (P = 0.019) and docosahexaenoic acid (DHA) (P = 0.015). A direct association was also observed between the whole blood and CSF omega-6 PUFA, arachidonic acid (AA) (P = 0.045). Interestingly an inverse association between central and peripheral oleic acid was also found (P = 0.045).

Conclusions

These findings indicate a relationship between central and peripheral fatty acids of varying degrees of unsaturation and chain length and support the view that some systemic fatty acids are likely to cross the human blood brain barrier (BBB) and thereby influence central fatty acid concentrations.

【 授权许可】

   
2013 Guest et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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