Relationship between central and peripheral fatty acids in humans

Lipids in Health and Disease

Research

Ayse Bilgin¹  Manohar Garg²  Jade Guest³  Ross Grant⁴ 

[1] Department of Statistics, Macquarie University, North Ryde, NSW, Australia;Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Newcastle, NSW, Australia;School of Medical Sciences, University of New South Wales, Wallace Wurth building, office #203, 2052, Sydney, NSW, Australia;Australasian Research Institute, Sydney Adventist Hospital, Sydney, NSW, Australia;School of Medical Sciences, University of New South Wales, Wallace Wurth building, office #203, 2052, Sydney, NSW, Australia;Australasian Research Institute, Sydney Adventist Hospital, Sydney, NSW, Australia;Sydney Adventist Hospital Clinical School, University of Sydney, Sydney, NSW, Australia;

关键词: Fatty acids;    Polyunsaturated fatty acids;    Brain;    Whole blood;    Cerebrospinal fluid;    Blood brain barrier;    Omega-3;    Omega-6;   

DOI  :  10.1186/1476-511X-12-79

 received in 2013-04-15, accepted in 2013-05-09,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundIn recent years the physiological and pathological importance of fatty acids in both the periphery and central nervous system (CNS) has become increasingly apparent. However surprisingly limited research has been conducted comparing the fatty acid composition of central and peripheral lipid stores.MethodsThe present study compared the distribution of polyunsaturated (PUFA), as well as specific saturated (SFA) and monounsaturated (MUFA) fatty acids in the whole blood and cerebrospinal fluid (CSF) of humans. Gas chromatography with flame ionization detection was used to determine the fatty acid profiles of twenty-eight matched CSF and whole blood samples. Multiple linear regression modeling, controlling for age, was used to identify significant relationships.ResultsA significant positive relationship was seen between whole blood total omega-3 fatty acids and the CSF omega-3 subfractions, docosapentaenoic acid (DPA) (P = 0.019) and docosahexaenoic acid (DHA) (P = 0.015). A direct association was also observed between the whole blood and CSF omega-6 PUFA, arachidonic acid (AA) (P = 0.045). Interestingly an inverse association between central and peripheral oleic acid was also found (P = 0.045).ConclusionsThese findings indicate a relationship between central and peripheral fatty acids of varying degrees of unsaturation and chain length and support the view that some systemic fatty acids are likely to cross the human blood brain barrier (BBB) and thereby influence central fatty acid concentrations.

【 授权许可】

Unknown   
© Guest et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.