Final Report on LDRD project 130784 : functional brain imaging by tunable multi-spectral Event-Related Optical Signal (EROS).

Speed, Ann Elizabeth ; Spahn, Olga Blum ; Hsu, Alan Yuan-Chun

Sandia National Laboratories

关键词: Biological Functions;    Infrared Spectra;    Resolution;    Brain;    Images;   

DOI  :  10.2172/993885
RP-ID  :  SAND2009-6266
RP-ID  :  AC04-94AL85000
RP-ID  :  993885

美国|英语

来源: UNT Digital Library

【 摘 要 】

Functional brain imaging is of great interest for understanding correlations between specific cognitive processes and underlying neural activity. This understanding can provide the foundation for developing enhanced human-machine interfaces, decision aides, and enhanced cognition at the physiological level. The functional near infrared spectroscopy (fNIRS) based event-related optical signal (EROS) technique can provide direct, high-fidelity measures of temporal and spatial characteristics of neural networks underlying cognitive behavior. However, current EROS systems are hampered by poor signal-to-noise-ratio (SNR) and depth of measure, limiting areas of the brain and associated cognitive processes that can be investigated. We propose to investigate a flexible, tunable, multi-spectral fNIRS EROS system which will provide up to 10x greater SNR as well as improved spatial and temporal resolution through significant improvements in electronics, optoelectronics and optics, as well as contribute to the physiological foundation of higher-order cognitive processes and provide the technical foundation for miniaturized portable neuroimaging systems.