Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis

BMC Pregnancy and Childbirth

Susan Tarawifa¹  Asro Hayani Harahap¹  Rina Nofri Enis¹  Mas Rizky Anggun Adipurna Syamsunarno²  Anggelia Puspasari³  Citra Maharani³  Amelia Dwi Fitri⁴  Herlambang Herlambang⁵  Huntari Harahap⁶  Erny Kusdiyah⁷ 

[1] Departement of Anatomy, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;Departement of Biomedical Sciences Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia;Departement of Medical Biology and Biochemistry, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;Departement of Medical Education, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;Departement of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;Departement of Physiology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;Departement of Physiology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;Departement of Public Health, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;

关键词: Fatty acid fraction;    Omega-3;    Omega-6;    Palmitoleic acid;    Preeclampsia;    Saturated fatty acid;   

DOI  :  10.1186/s12884-021-04313-3

来源: Springer

【 摘 要 】

BackgroundPreeclampsia is a complication during pregnancy characterised by new-onset hypertension and proteinuria that develops after 20 weeks of gestation. Dyslipidemia in pregnancy is correlated with an increased risk of preeclampsia. However, the dynamic changes in lipid metabolic product, particularly fatty acid fraction, in preeclampsia maternal circulation, are not well understood. This study aimed to investigate fatty acid fraction in preeclampsia maternal blood compared with normotensive normal pregnancy.MethodsA total of 34 women who developed preeclampsia and 32 women with normotensive normal pregnancy were included in our case-control study. Maternal blood samples were collected for serum fatty acid fractions analysis and other biochemical parameters. Serum fatty acid fractions included long-chain polyunsaturated fatty acid (LCPUFA), monounsaturated fatty acid (MUFA), saturated fatty acid, and total fatty acid, measured with gas chromatography-mass spectrometry (GC-MS). The mean difference of fatty acid level was analysed using parametric and non-parametric bivariate analysis based on normality distributed data, while the risk of preeclampsia based on fatty acid fraction was analysed using a logistic regression model.ResultsWomen with preeclampsia have lower high-density lipoprotein (53.97 ± 12.82 mg/dL vs. 63.71 ± 15.20 mg/dL, p = 0.006), higher triglyceride (284.91 ± 97.68 mg/dL vs. 232.84 ± 73.69 mg/dL, p = 0.018) than that in the normotensive group. Higher palmitoleic acid was found in women with preeclampsia compared to normotensive normal pregnancy (422.94 ± 195.99 vs. 325.71 ± 111.03 μmol/L, p = 0.037). The binary logistic regression model showed that pregnant women who had total omega-3 levels within the reference values had a higher risk of suffering preeclampsia than those with the higher reference value (odds ratio OR (95% CI): 8,5 (1.51–48.07), p = 0.015). Pregnant women who have saturated fatty acid within reference values had a lower risk for suffering preeclampsia than those in upper reference value (OR (95% CI): 0.21 (0.52–0.88), p = 0.032).ConclusionOverall, palmitoleic acid was higher in women with preeclampsia. Further analysis indicated that reference omega-3 in and high saturated fatty acid serum levels are characteristics of women with preeclampsia.

【 授权许可】

CC BY