A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats

Lipids in Health and Disease

Fenghong Huang²  Qingde Huang²  Qianchun Deng²  Wei Yang⁴  Chang Chen³  Li Zhang¹  Hui Gao⁴  Jiqu Xu² 

[1] Department of neurology, Hubei Xinhua Hosipital, 11 lingjiaohu Road, Wuhan 430015, P.R. China;Hubei Key Laboratory of Lipid Chemistry and Nutrition, OilCrops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P.R. China;Department of Gastroenterology, The People's Hospital of China Three Gorges University, 2 Jiefang Road, Yichang 443000, P.R. China;Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, P.R. China

关键词: Inflammation;    Plasma lipids;    Oxidant stress;    Atherosclerosis;    Astaxanthin;    Flaxseed oil;   

Others  :  805192
DOI  :  10.1186/1476-511X-13-63

 received in 2014-01-24, accepted in 2014-03-04,  发布年份 2014

【 摘 要 】

Background

Atherosclerosis is the most common pathologic process underlying cardiovascular disease. Both flaxseed oil (FO) and astaxanthin (ASX) are believed to benefit cardiovascular system. The combined effect of FO and ASX on the atherosclerosis risk factors in rats fed a high-fat diet was investigated.

Methods

Astaxanthin was dissolved in flaxseed oil to a final concentration of 1g/kg (FO + ASX). Male Sprague–Dawley rats were fed a rodent diet contained 20% fat whose source was lard (HFD) or 75% lard and 25% FO + ASX (50 mg ASX/kg diet) or 50% lard and 50% FO + ASX (100 mg ASX/kg diet) or FO + ASX (200 mg ASX/kg diet) for 10 weeks.

Results

The combination of FO and ASX significantly increased the antioxidant defense capacity and decreased lipid peroxidation in plasma. Evident decreases in the levels TG, TC and LDL-C contents, as well as IL-6 and CRP were also observed in plasma of FO and ASX fed rats.

Conclusion

The combination of FO and ASX can improve oxidative stress, lipid abnormalities and inflammation, providing evidence that the combination of FO and ASX could be a promising functional food in cardiovascular health promotion.

【 授权许可】

   
2014 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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