Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet

Lipids in Health and Disease

Fenghong Huang¹  Jin’e Yang¹  Qingde Huang¹  Qianchun Deng¹  Wei Yang²  Jiqu Xu¹ 

[1] Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crop s Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan, 430062, P.R. China;Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, P.R. China

关键词: Inflammation;    Plasma lipids;    Oxidant stress;    Atherosclerosis;    α-lipoic acid;    Flaxseed oil;   

Others  :  1160156
DOI  :  10.1186/1476-511X-11-148

 received in 2012-07-05, accepted in 2012-10-26,  发布年份 2012

【 摘 要 】

Background

Atherosclerosis is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and α-lipoic acid (LA) have been reported to exert potential benefit to cardiovascular system. This study tried to assess the effect of supplement of FO and LA combination on the atherosclerosis risk factors in rats fed a high-fat diet.

Methods

LA was dissolved in flaxseed oil to a final concentration of 8 g/kg (FO+LA) when used. The rodent diet contained 20% fat. One-fifth of the fat was soybean oil and the others were lard (HFD group), or 75% lard and 25% FO+LA (L-FO+LA group), or 50% lard and 50% FO+LA (M-FO+LA group), or FO+LA (H-FO+LA group). Animals were fed for 10 weeks and then killed for blood collection.

Results

Supplement of FO and LA combination significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the activities of SOD, CAT and GPx as well as the level of GSH, and the significant reduction in lipid peroxidation. Simultaneous intake of FO and LA also reduced plasma TG, TC and LDL-C contents and elevated the ratio of HDL-C/LDL-C. Besides, in parallel with the increase of FO and LA combination, plasma IL-6 and CRP levels were remarkably reduced.

Conclusion

Supplement of FO and LA combination may contribute to prevent atherogenesis by improving plasma oxidative stress, lipid profile and inflammation.

【 授权许可】

   
2012 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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