A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats

Lipids in Health and Disease

Research

Chang Chen¹  Wei Yang²  Hui Gao²  Qianchun Deng³  Fenghong Huang³  Qingde Huang³  Jiqu Xu³  Li Zhang⁴ 

[1] Department of Gastroenterology, The First People's Hospital of Yichang, The People's Hospital of China Three Gorges University, 2 Jiefang Road, 443000, Yichang, P.R. China;Department of Gastroenterology, The People's Hospital of China Three Gorges University, 2 Jiefang Road, 443000, Yichang, P.R. China;Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, 430030, Wuhan, P.R. China;Department of Product Processing and Nutriology, OilCrops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, P.R. China;Hubei Key Laboratory of Lipid Chemistry and Nutrition, OilCrops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, P.R. China;Department of neurology, Hubei Xinhua Hosipital, 11 lingjiaohu Road, 430015, Wuhan, P.R. China;

关键词: Flaxseed oil;    Astaxanthin;    Atherosclerosis;    Oxidant stress;    Plasma lipids;    Inflammation;   

DOI  :  10.1186/1476-511X-13-63

 received in 2014-01-24, accepted in 2014-03-04,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAtherosclerosis is the most common pathologic process underlying cardiovascular disease. Both flaxseed oil (FO) and astaxanthin (ASX) are believed to benefit cardiovascular system. The combined effect of FO and ASX on the atherosclerosis risk factors in rats fed a high-fat diet was investigated.MethodsAstaxanthin was dissolved in flaxseed oil to a final concentration of 1g/kg (FO + ASX). Male Sprague–Dawley rats were fed a rodent diet contained 20% fat whose source was lard (HFD) or 75% lard and 25% FO + ASX (50 mg ASX/kg diet) or 50% lard and 50% FO + ASX (100 mg ASX/kg diet) or FO + ASX (200 mg ASX/kg diet) for 10 weeks.ResultsThe combination of FO and ASX significantly increased the antioxidant defense capacity and decreased lipid peroxidation in plasma. Evident decreases in the levels TG, TC and LDL-C contents, as well as IL-6 and CRP were also observed in plasma of FO and ASX fed rats.ConclusionThe combination of FO and ASX can improve oxidative stress, lipid abnormalities and inflammation, providing evidence that the combination of FO and ASX could be a promising functional food in cardiovascular health promotion.

【 授权许可】

Unknown   
© Xu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.