Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study

BMC Gastroenterology

Katri Kaukinen²  Markku Mäki¹  Heini Huhtala⁴  Pekka Collin³  Anniina Ukkola¹  Kalle Kurppa¹  Pilvi Paarlahti¹ 

[1] Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland;Seinäjoki Central Hospital, Seinäjoki, Finland;Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland;Tampere School of Health Sciences, University of Tampere, Tampere, Finland

关键词: Adults;    Gluten-free diet;    Quality of life;    Symptoms;    Coeliac disease;   

Others  :  858022
DOI  :  10.1186/1471-230X-13-75

 received in 2012-09-13, accepted in 2013-04-16,  发布年份 2013

【 摘 要 】

Background

Evidence suggests that many coeliac disease patients suffer from persistent clinical symptoms and reduced health-related quality of life despite a strict gluten-free diet. We aimed to find predictors for these continuous health concerns in long-term treated adult coeliac patients.

Methods

In a nationwide study, 596 patients filled validated Gastrointestinal Symptom Rating Scale and Psychological General Well-Being questionnaires and were interviewed regarding demographic data, clinical presentation and treatment of coeliac disease, time and place of diagnosis and presence of coeliac disease-associated or other co-morbidities. Dietary adherence was assessed by a combination of self-reported adherence and serological tests. Odds ratios and 95% confidence intervals were calculated by binary logistic regression.

Results

Diagnosis at working age, long duration and severity of symptoms before diagnosis and presence of thyroidal disease, non-coeliac food intolerance or gastrointestinal co-morbidity increased the risk of persistent symptoms. Patients with extraintestinal presentation at diagnosis had fewer current symptoms than subjects with gastrointestinal manifestations. Impaired quality of life was seen in patients with long duration of symptoms before diagnosis and in those with psychiatric, neurologic or gastrointestinal co-morbidities. Patients with persistent symptoms were more likely to have reduced quality of life.

Conclusions

There were a variety of factors predisposing to increased symptoms and impaired quality of life in coeliac disease. Based on our results, early diagnosis of the condition and consideration of co-morbidities may help in resolving long-lasting health problems in coeliac disease.

【 授权许可】

   
2013 Paarlahti et al.; licensee BioMed Central Ltd.

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