Pathomics: Final Report

Turteltaub, K W ; Ascher, M ; Langlois, R ; Fodor, I ; Kercher, J ; Laughlin, K M ; Nelson, D ; Colston, W ; Milanovich, F P

Lawrence Livermore National Laboratory

关键词: Diseases;    Monitoring;    59 Basic Biological Sciences;    Symptoms;    Detection;   

DOI  :  10.2172/1036867
RP-ID  :  UCRL-TR-226770
RP-ID  :  W-7405-ENG-48
RP-ID  :  1036867

美国|英语

来源: UNT Digital Library

【 摘 要 】

Pathomics is a research project to explore the feasibility for developing biosignatures for early infectious disease detection in humans, particularly those that represent a threat from bioterrorism. Our goal is to use a science-based approach to better understand the underlying molecular basis of disease and to find sensitive, robust, and specific combinations of biological molecules (biosignatures) in the host that will indicate the presence of developing infection prior to overt symptoms (pre-syndromic). The ultimate goal is develop a national surveillance system for monitoring for the release and managing the consequences of a biothreat agent or an emerging disease. Developing the science for a more comprehensive understanding of the molecular basis of infectious disease and the development of biosignature-based diagnostics could help detect both emerging and engineered treats to humans.