A 3-D Model of Signaling and Transport Pathways in Epithelial Cells

Quong, Andrew A. ; Westbrook, Charles K.

Lawrence Livermore National Laboratory

关键词: Diseases;    Calcium Ions;    Computers;    37 Inorganic, Organic, Physical And Analytical Chemistry;    59 Basic Biological Sciences;   

DOI  :  10.2172/15015950
RP-ID  :  UCRL-TR-211112
RP-ID  :  W-7405-ENG-48
RP-ID  :  15015950

美国|英语

来源: UNT Digital Library

【 摘 要 】

A 3-dimensional computer model was developed to simulate the spatial and chemical evolution of calcium ions inside an array of human epithelial kidney cells. This is a prototype model, intended to develop a methodology to incorporate much more complex interactions of metabolic and other processes within many types of cells and lead to increased ability to predict cellular responses to disease as well as to chemical and biological warfare situations. Preliminary tests of the model are described.