Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study

BMC Gastroenterology

Research Article

Pekka Collin¹  Katri Kaukinen²  Kalle Kurppa³  Anniina Ukkola³  Markku Mäki³  Pilvi Paarlahti³  Heini Huhtala⁴ 

[1] Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland;Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland;Seinäjoki Central Hospital, Seinäjoki, Finland;Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland;Tampere School of Health Sciences, University of Tampere, Tampere, Finland;

关键词: Coeliac disease;    Symptoms;    Quality of life;    Gluten-free diet;    Adults;   

DOI  :  10.1186/1471-230X-13-75

 received in 2012-09-13, accepted in 2013-04-16,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundEvidence suggests that many coeliac disease patients suffer from persistent clinical symptoms and reduced health-related quality of life despite a strict gluten-free diet. We aimed to find predictors for these continuous health concerns in long-term treated adult coeliac patients.MethodsIn a nationwide study, 596 patients filled validated Gastrointestinal Symptom Rating Scale and Psychological General Well-Being questionnaires and were interviewed regarding demographic data, clinical presentation and treatment of coeliac disease, time and place of diagnosis and presence of coeliac disease-associated or other co-morbidities. Dietary adherence was assessed by a combination of self-reported adherence and serological tests. Odds ratios and 95% confidence intervals were calculated by binary logistic regression.ResultsDiagnosis at working age, long duration and severity of symptoms before diagnosis and presence of thyroidal disease, non-coeliac food intolerance or gastrointestinal co-morbidity increased the risk of persistent symptoms. Patients with extraintestinal presentation at diagnosis had fewer current symptoms than subjects with gastrointestinal manifestations. Impaired quality of life was seen in patients with long duration of symptoms before diagnosis and in those with psychiatric, neurologic or gastrointestinal co-morbidities. Patients with persistent symptoms were more likely to have reduced quality of life.ConclusionsThere were a variety of factors predisposing to increased symptoms and impaired quality of life in coeliac disease. Based on our results, early diagnosis of the condition and consideration of co-morbidities may help in resolving long-lasting health problems in coeliac disease.

【 授权许可】

Unknown   
© Paarlahti et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.