Dietary guanidino acetic acid spares arginine and dietary l-homoserine spares threonine in the chick

Guanidino acetic acid;L-Homoserine;spares;Arginine;Threonine;chick

Bryant-Angeloni, Kasey I. ; Parsons ; Carl M. ; Baker ; David H.

关键词: Guanidino acetic acid;    L-Homoserine;    spares;    Arginine;    Threonine;    chick;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/16151/Bryant-Angeloni_Kasey.pdf?sequence=2&isAllowed=y

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来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Guanidino acetic acid (GAA) is synthesized in the liver and kidney from Arg and Gly.It is subsequently methyllated by S-adenosylmethione to creatine.L-Homoserine (HS) has been identified as an intermediate compound in the metabolism of Thr, Met, and Asp.Bacteria, plants and yeast can synthesize Thr and Met from HS, but this has not been shown in higher organisms.Several bioassays were carried out to determine the capacity of GAA to spare dietary Arg or HS to spare dietary Thr.Crossbred chicks were fed Arg-deficient dextrose-casein (0.86% Arg), Arg-deficient corn-corn coproduct-soybean meal (1.0% Arg), Thr-deficient dextrose-casein (0.22% Thr), or Thr-deficient corn-peanut meal (0.46%) basal diets during 9-d battery feeding trials involving 5 pens of 4 chicks per treatment.Growth and gain:feed responses were obtained when GAA was added to a purified Arg-deficient diet and when HS was added to both Thr-deficient diets.In the corn-corn coproduct-soybean meal diet, GAA yielded a gain:feed response, but not an increase in gain. These results demonstrate that 0.12% supplemental GAA, like creatine, produces consistent growth and feed efficiency responses in young chicks fed Arg-deficient diets and indicate that low levels of HS (0.08-0.1%) elicit a growth and feed efficiency response in young chicks fed Thr-deficient diets.