期刊论文详细信息
BMC Nephrology
The effect of oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine on wound healing: a retrospective analysis of diabetic haemodialysis patients
Ali Tamer1  Mustafa Cahit Demirci2  Mehmet Cilci2  Mehmet Gunduz3  Ozkan Gungor4  Savas Sipahi5 
[1] Clinic of Internal Diseases, Sakarya University Training and Research Hospital, Sakarya, Turkey;Private Nefromed Hemodialysis Center, Sakarya, Turkey;Clinic of Internal Diseases, Yozgat State Hospital, Yozgat, Turkey;Department of Nephrology, Ege University Faculty of Medicine, Izmir, Turkey;Clinic of Nephrology, Sakarya University Training and Research Hospital, Adnan Menderes Cad. Saglik Sok. No: 193, Adapazari, Sakarya, Turkey
关键词: Hydroxy methylbutyrate;    Glutamine;    Arginine;    Oral nutrition support;    Haemodialysis;    Diabetic foot;   
Others  :  1083030
DOI  :  10.1186/1471-2369-14-8
 received in 2012-07-26, accepted in 2013-01-07,  发布年份 2013
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【 摘 要 】

Background

Diabetes is an important reason for end-stage renal failure and diabetic foot wounds worsen the life qualities of these patients. Protein and amino acid support accelerates the wound healing. The purpose of this retrospective study is to examine the effect of beta-hydroxy-beta-methylbutyrate, arginine and glutamine (Abound®) supplementation on the wound healing.

Methods

A total of 11 diabetic dialysis patients were included in this retrospective study aiming to evaluate the effect of the diet support with beta-hydroxy-beta-methylbutyrate, arginine and glutamine on wound healing in diabetic dialysis patients. Pre-treatment and post-treatment wound depth and wound appearance were scored in accordance with the “Bates-Jensen” wound assessment tool. The results of 4-week treatment with beta-hydroxy-beta-methylbutyrate, arginine and glutamine (Abound®) support were evaluated in terms of wound healing.

Results

The mean age of patients was 66 (SD: 10, range: 51-81) and 9 (81.8%) of them were males. After the 4-week treatment, in accordance with the Bates-Jensen scoring, healing was observed on the wound depth score of 7(63.6%) patients and on wound appearance score of 8(72.7%) patients out of 11. While the wound depth score of 4(36.4%) cases and wound appearance score of 3(27.3%) cases remained the same, no deterioration was observed on any cases throughout the follow-up period.

Conclusion

In conclusion, our findings revealed that Abound treatment makes a positive contribution to the wound healing in diabetic dialysis patients.

【 授权许可】

   
2013 Sipahi et al; licensee BioMed Central Ltd.

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