Human Genetic Marker for Resistance to Radiations and Chemicals

Lieberman, Howard B.

Columbia University, New York, NY (United States)

关键词: 63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;    Dna Damages;    Dna;    Genetics;    Fission;   

DOI  :  10.2172/827399
RP-ID  :  EMSP-55100--2000
RP-ID  :  FG07-96ER62309
RP-ID  :  827399

美国|英语

来源: UNT Digital Library

【 摘 要 】

The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 and determination of its role in mediating the cellular response to radiations and chemicals, as well as its potential role in carcinogenesis.