Human Genetic Marker for Resistance to Radiation and Chemicals

Lieberman, DR. Howard B.

Columbia University. Trustees.

关键词: 63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;    Dna Damages;    Genetics;    Genes;    Chemical Wastes Radiations;   

DOI  :  10.2172/789807
RP-ID  :  DOE/ER/62309
RP-ID  :  FG07-96ER62309
RP-ID  :  789807

美国|英语

来源: UNT Digital Library

【 摘 要 】

TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage.