Simultaneous Quantitation of Atenolol, Metoprolol, and Propranolol in Biological Matrices Via LC/MS

Johnson RD, Lewis RJ

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Forensic Science;    Toxicology;    Liquid Chromatography/ Mass Spectrometery;    Atenolol;    Metoprolol;    Propranolol;   

RP-ID  :  DOT/FAA/AM-05/10

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

Hypertension is a growing medical concern in the United States. With the number of Americans suffering from hypertension increasing, the use of antihypertensives such as beta-blockers is increasing as well. In fact, three beta-blockers � atenolol, metoprolol and propranolol � were among the 200 most prescribed medications in the United States in 2003. Pilots that successfully manage their hypertension can remain certified to fly. The Federal Aviation Administration currently designates approximately 8% of active pilots as �hypertensive with medication.� The Civil Aerospace Medical Institute (CAMI) performs toxicological evaluation on victims of fatal aviation accidents. At CAMI beta-blockers are analyzed using gas chromatography with mass spectrometric detection.