Distribution of Δ9-Tetrahydrocannabinol and 11-Nor-9-Carboxy-Δ9-Tetrahydrocannabinol in Postmortem Biological Fluids and Tissues From Pilots Fatally Injured in Aviation Accidents

Kemp PM, Cardona PS, Chaturvedi AK, Soper JW

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Forensic Science;    Toxicology;    Marijuana;    Cannabinoids;    Δ⁹-Tetrahydrocannabinol (THC);    11-nor-9-carboxy-Δ⁹-Tetrahydrocannabinol (THCCOOH);    Postmortem;    Distribution;    Pilot Fatalities;    Aircraft Accident Investigation;   

RP-ID  :  DOT/FAA/AM-13/24

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

Despite a long history of research on the pharmacology of Δ⁹-tetrahydrocannabinol (THC), the primary active cannabinoid in marijuana, little is known of its distribution in postmortem fluids and tissues. This study presents postmortem fluid and tissue data for THC and its major metabolite, 11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol (THCCOOH), from 55 pilots involved in fatal aviation accidents from 2005 - 2012.