A novel method for the determination of sildenafil (Viagra�) and its metabolite in postmortem specimens using LC/MS/MS and LC/MS/MS

Lewis, R.J., Johnson, R.D., and Blank, C.L.

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Forensic Science;    Toxicology;    Erectile Dysfunction;    Sildenafil;    Viagra;    LC/MS;    LC/MS/MS;    LC/MS/MS/MS;    Aircraft Accident Investigation;   

RP-ID  :  DOT/FAA/AM-00/20

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

During the investigation of aviation accidents, postmortem samples from victims are submitted to the FAA's Civil Aerospace Medical Institute for drug analysis. Because new drugs are continually being released to the market, it is our laboratory's responsibility to develop methods which can identify these new drugs. This paper presents a rapid and reliable method for the identification and quantitation of sildenafil (Viagra�) and its metabolite, UK-103,320. Sildenafil, when used properly, is relatively safe. There are, however, certain side effects that could create potential hazards. For example, Sildenafil has been shown to potentiate the hypotensive effects of nitrates commonly employed in the treatment of certain heart conditions.