Gas Chromatographic/Mass Spectrometric Differentiation of Atenolol, Metoprolol, Propranolol, and an Interfering Metabolite Product of Metoprolol

Angier MK, Lewis RJ, Chaturvedi AK, and Canfield DV

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Forensic Science;    Toxicology;    Gas Chromatography/ Mass Spectrometery;    Atenolol;    Metoprolol;    Propranolol;    Interfering Metoprolol Metabolite Product;   

RP-ID  :  DOT/FAA/AM-04/15

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

Pilots who successfully control their hypertension with medications, diet, and/or exercise can be medically certified to fly an aircraft. At the present time, approximately 8% of active pilots are designated as "hypertensive with medication" by the Federal Aviation Administration (FAA). One of the groups of antihypertensives is the beta-blocker. Of this group, atenolol, metoprolol, and propranolol are commonly prescribed, and they also have chemical and structural similarities.