JOURNAL OF CONTROLLED RELEASE | 卷:156 |
Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds | |
Article | |
Choi, Jonghoon1,2,3  Kim, Kyobum4  Kim, Taeho1,2,6  Liu, Guanshu1,2,7  Bar-Shir, Amnon1,2  Hyeon, Taeghwan6  McMahon, Michael T.1,2,7  Bulte, Jeff W. M.1,2,8,9  Fisher, John P.5  Gilad, Assaf A.1,2,7  | |
[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Div MR Res, Baltimore, MD 21218 USA | |
[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Cellular Imaging Sect, Baltimore, MD USA | |
[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA | |
[4] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA | |
[5] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA | |
[6] Seoul Natl Univ, Sch Chem & Biol Engn, Natl Creat Res Initiat Ctr Oxide Nanocrystalline, Seoul, South Korea | |
[7] FM Kirby Ctr, Kennedy Krieger Inst, Baltimore, MD USA | |
[8] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA | |
[9] Johns Hopkins Univ, Sch Med, Dept Chem & Biomol Engn, Baltimore, MD USA | |
关键词: Nanoparticles; Poly(propylene fumarate) (PPF); Magnetic resonance imaging (MRI); Chemical exchange saturation transfer (CEST); Protamine sulfate (PS) drug release; Doxorubicin; | |
DOI : 10.1016/j.jconrel.2011.06.035 | |
来源: Elsevier | |
【 摘 要 】
The potential of poly(propylene fumarate) (PPF) scaffolds as drug carriers was investigated and the kinetics of the drug release quantified using magnetic resonance imaging (MRI) and optical imaging. Three different MR contrast agents were used for coating PPF scaffolds. Initially, iron oxide (IONP) or manganese oxide nanoparticles (MONP) carrying the anti-cancer drug doxorubicin were absorbed or mixed with the scaffold and their release into solution at physiological conditions was measured with MRI and optical imaging. A slow (hours to days) and functional release of the drug molecules into the surrounding solution was observed. In order to examine the release properties of proteins and polypeptides, protamine sulfate, a chemical exchange saturation transfer (CEST) MR contrast agent, was attached to the scaffold. Protamine sulfate showed a steady release rate for the first 24 h. Due to its biocompatibility, versatile drug-loading capability and constant release rate, the porous PPF scaffold has potential in various biomedical applications, including MR-guided implantation of drug-dispensing materials, development of drug carrying vehicles, and drug delivery for tumor treatment. (C) 2011 Elsevier B. V. All rights reserved.
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