Engineering nanolayered particles for modular drug delivery

JOURNAL OF CONTROLLED RELEASE

卷:240

Article

Correa, Santiago^1,2  Dreaden, Erik C.^1,3  Gu, Li^1,3  Hammond, Paula T.^1,3,4 

[1] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

关键词: Layer-by-layer;    Nanoparticles;    Controlled release;    Drug delivery;    Gene delivery;    Combination therapy;    Diagnostics;    Theranostics;    Active targeting;    Colloid chemistry;    Polymer engineering;    Biomaterials;    Scalable synthesis;    Shelf life;    Clinical translation;   

DOI  :  10.1016/j.jconrel.2016.01.040

来源: Elsevier

【 摘 要 】

Layer-by-layer (LbL) based self-assembly of nanoparticles is an emerging and powerful method to develop multifunctional and tissue responsive nanomedicines for a broad range of diseases. This unique assembly technique is able to confer a high degree of modularity, versatility, and compositional heterogeneity to nanoparticles via the sequential deposition of alternately charged polyelectrolytes onto a colloidal template. LbL assembly can provide added functionality by directly incorporating a range of functional materials within the multilayers including nucleic acids, synthetic polymers, polypeptides, polysaccharides, and functional proteins. These materials can be used to generate hierarchically complex, heterogeneous thin films on an extensive range of both traditional and novel nanoscale colloidal templates, providing the opportunity to engineer highly precise systems capable of performing the numerous tasks required for systemic drug delivery. In this review, we will discuss the recent advancements towards the development of LbL nanoparticles for drug delivery and diagnostic applications, with a special emphasis on the incorporation of biostability, active targeting, desirable drug release kinetics, and combination therapies into LbL nanomaterials. In addition to these topics, we will touch upon the next steps for the translation of these systems towards the clinic. (C) 2016 Published by Elsevier B.V.

【 授权许可】

Free