Supramolecular nanoscale assemblies for cancer diagnosis and therapy

JOURNAL OF CONTROLLED RELEASE

卷:213

Review

Coelho, Silvia Castro¹  Pereira, Maria Carmo¹  Juzeniene, Asta²  Juzenas, Petras²  Coelho, Manuel A. N.¹ 

[1] Univ Porto, Fac Engn, Dept Chem Engn, LEPABE, P-4200465 Porto, Portugal

[2] Univ Hosp, Radium Hosp, Inst Canc Res, Dept Radiat Biol, NO-0310 Oslo, Norway

关键词: Chemotherapy;    Drug delivery systems;    Gold nanoparticles;    Polymeric nanoparticles;    Internalization;    Radiotherapy;   

DOI  :  10.1016/j.jconrel.2015.06.034

来源: Elsevier

【 摘 要 】

Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy and radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free