Gold nanoparticles as a drug delivery system for standard chemotherapeutics: A new lead for targeted pharmacological cancer treatments

Scientific African

Amine Ousaid¹  Mohamed Yafout²  Youssef Khayati³  Ibrahim Sbai El Otmani³ 

[1] Laboratory of Drug Sciences, Biomedical and Biotechnological Research, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco;Corresponding author at: Laboratory of Drug Sciences, Biomedical and Biotechnological Research. Faculty of Medicine and Pharmacy of Casablanca. Hassan II University, 19, Tarik Ibnou Ziad St, PO Box 9154 Casablanca, Morocco.;Laboratory of Drug Sciences, Biomedical and Biotechnological Research, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco;

关键词: Gold nanoparticles;    Cancer;    Chemotherapy;    Targeted therapies;    Drug delivery;   

DOI  :  

来源: DOAJ

【 摘 要 】

Despite the great progress in medical sciences, cancer is still a major health problem. Since the majority of cancer treatment protocols include first-generation chemotherapeutic agents, side effects and drug resistance are still a concerning issue. Therefore, targeted and selective solution for standard chemotherapeutics is needed more than ever. Gold nanoparticles (GNPs) have remarkable size and surface properties that make them the ideal vehicle for targeted and selective drug delivery. Different in vitro and in vivo experiments proved that these particles can be easily engineered in such a way that the chemical drug can be delivered directly to the tumor site. Moreover, different types of ligands can be loaded on the surface of GNPs to enhance selectivity or modulate drug release. Furthermore, the anti-angiogenic and photothermal properties of these particles can be used to potentialize the drug action. However, more studies must be conducted to elucidate all the toxicity issues and to acquire additional knowledge on the long-term health effects and interaction with all the human body's physiological mechanisms.

【 授权许可】

Unknown