Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy

Journal of Nanobiotechnology

Jingchao Li¹  Zongyu Xie²  Haitao Sun³  Xiaofeng Zhu⁴  Zeliang Xuan⁴  Xiaoying Wang⁴ 

[1] College of Chemistry, Chemical Engineering and Biotechnology, Donghua University;Department of Radiology, The First Affiliated Hospital of Bengbu Medical College;Shanghai Institute of Medical Imaging, Department of Interventional Radiology, Zhongshan Hospital, Fudan University;Xuhui District Center for Disease Control and Prevention;

关键词: Drug delivery systems;    Near-infrared light;    Nanomaterials;    Chemotherapy;    Phototherapy;   

DOI  :  10.1186/s12951-020-00668-5

来源: DOAJ

【 摘 要 】

Abstract Drug delivery systems (DDSs) based on nanomaterials have shown a promise for cancer chemotherapy; however, it remains a great challenge to localize on-demand release of anticancer drugs in tumor tissues to improve therapeutic effects and minimize the side effects. In this regard, photoresponsive DDSs that employ light as an external stimulus can offer a precise spatiotemporal control of drug release at desired sites of interest. Most photoresponsive DDSs are only responsive to ultraviolet-visible light that shows phototoxicity and/or shallow tissue penetration depth, and thereby their applications are greatly restricted. To address these issues, near-infrared (NIR) photoresponsive DDSs have been developed. In this review, the development of NIR photoresponsive DDSs in last several years for cancer photo-chemotherapy are summarized. They can achieve on-demand release of drugs into tumors of living animals through photothermal, photodynamic, and photoconversion mechanisms, affording obviously amplified therapeutic effects in synergy with phototherapy. Finally, the existing challenges and further perspectives on the development of NIR photoresponsive DDSs and their clinical translation are discussed.

【 授权许可】

Unknown