Outstanding Questions in Mitophagy: What We Do and Do Not Know

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Review

Montava-Garriga, Lambert¹  Ganley, Ian G.¹ 

[1] Univ Dundee, MRC Prot Phosphorylat & Ubiquitylat Unit, Sch Life Sci, Dundee DD1 5EH, Scotland

关键词: mitophagy;    mitochondria;    Parkinson's disease;    autophagy;    metabolism;   

DOI  :  10.1016/j.jmb.2019.06.032

来源: Elsevier

【 摘 要 】

The elimination of mitochondria via autophagy, termed mitophagy, is an evolutionarily conserved mechanism for mitochondrial quality control and homeostasis. Mitophagy, therefore, has an important contribution to cell function and integrity, which extends to the whole organism for development and survival. Research in mitophagy has boomed in recent years, and it is becoming clear that mitophagy is a complex and multi-factorial cellular response that depends on tissue, energetic, stress and signaling contexts. However, we know very little of its physiological regulation and the direct contribution of mitophagy to pathologies like neurodegenerative diseases. In this review, we aim to discuss the outstanding questions (and questions outstanding) in the field and reflect on our current understanding of mitophagy, the current challenges and the future directions to take. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free